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KMID : 1143420230160160496
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Public Health Weekly Report
2023 Volume.16 No. 16 p.496 ~ p.518
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Result of the Surveillance System for Acute Hepatitis of Unknown Etiology in Children in the Republic of Korea
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Park Eun-Kyung
Seo Soon-Ryu
Gwack Jin
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Abstract
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Acute hepatitis of unknown etiology was reported to be increasing in cases under the age of 10 in the UK Health Security Agency in April 2022, and probable cases have been reported in many countries such as the UK and the United States. The Korea Disease Control and Prevention Agency established a surveillance system for acute hepatitis of unknown etiology in children for approximately seven months, from May 1 to December 2, 2022 in cooperation with experts and related societies to identify the domestic outbreak situation and determine the causes. A case of acute hepatitis of unknown etiology in children in the Republic of Korea (ROK) was defined as a person presenting with acute hepatitis (non-hepatitis viruses A, B, C, and E) with serum transaminase levels greater than 500 IU/L (aspartate aminotransferase [AST] or alanine aminotransferase [ALT]), aged 16 years or older, since May 1, 2022. A total of 82 cases, excluding a case that did not meet the case definition, were identified as 66 cases met the case definition, and 16 cases could not be evaluated. 12 (14.6%) and 4 (4.9%) cases tested positive for adenovirus and adeno-associated virus type 2 using polymerase chain reaction testing, respectively. Four cases (4.9%) underwent liver transplantation, wherein no death occurred. Additionally, no specific trend by time or season was identified regarding the outbreak in the ROK.
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KEYWORD
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Hepatitis, Public health surveillance, Communicable diseases
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